Журнал детской медицины и хирургии

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The Intriguing Near-IR Quantum Dots could be used to Differentiate Stem Cells Using Growth Factors

Hassan Niknejad

For somatic cell medical care of chronic diseases, it's necessary to differentiate stem cells into the particular lineage. There are a unit many growth factors that are used for differentiation of stem cells. Some issue protein}s will dose-dependently induce differentiation of stem cells so the rise of growth factor concentration ends up in production of the upper level of differentiated cells. However, because of the toxicity of some differentiation factors (e.g. retinoic acid), the lower dose of growth factors for the particular lineage differentiation of stem cells is fascinating. This paper suggests a brand new approach within the field of controlled protein delivery system victimisation semiconductor nanocrystals; referred to as quantum dots (QDs). This method contains chemical compound microencapsulated protein that is conjugated to close infrared (NIR) interesting QDs [1]. The management unharness of growth factors from microcapsules within the culture plates are often achieved by irradiation. To modulate protein unharness in response to stem cells wants for differentiation, the intensity and amount of irradiation are controlled. Our hypothesis is predicated on the actual fact that QDs will absorb NIR energy and by excitation of electrons so undulation relaxation of them become heated once they were irradiated so unharness growth factors. We have a tendency to believe that controlled growth factors delivery through the instructed system is an efficient technique to scale back the quantity of growth factors needed for differentiation of stem cells.