Журнал цитокиновой биологии

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The Significance of Anti-inflammatory Cytokines in Immune Response Modulation and Inflammation Dampening

Chun Hui

Inflammation is a complex biological response that plays a vital role in the immune system’s defense mechanisms against harmful stimuli. However, excessive or prolonged inflammation can lead to tissue damage and contribute to the development of various chronic diseases. To counterbalance the pro-inflammatory effects, antiinflammatory cytokines act as essential modulators, regulating the immune response and dampening inflammation. Anti-inflammatory cytokines are a class of signaling molecules produced by various immune and non-immune cells in response to inflammatory stimuli. These cytokines, including interleukin-10 (IL-10), transforming growth factorbeta (TGF-β), and IL-1 receptor antagonist (IL-1ra), exert potent immunosuppressive and anti-inflammatory effects. The primary role of anti-inflammatory cytokines is to downregulate the production and activity of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). They achieve this by inhibiting the activation of immune cells, suppressing the production of inflammatory mediators, and promoting the differentiation and function of regulatory immune cells. Through their regulatory functions, antiinflammatory cytokines contribute to maintaining immune homeostasis and preventing excessive tissue damage. They play crucial roles in resolving inflammation after an acute immune response, promoting tissue repair, and preventing the development of chronic inflammatory conditions. Dysregulation or deficiency of anti-inflammatory cytokines can lead to unchecked inflammation and heightened susceptibility to inflammatory diseases.