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The Synchronicity of Chronic Lymphocytic Leukemia and Multiple Myeloma in a Bone Marrow Biopsy with Therapy Discussion

Zofia Tynski, Ikkei Hirama and James M. Rossetti

The coexistence of synchronous chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in a bone marrow of a patient is a very rare occurrence. To our knowledge, only four publications were reported in the English literature. Herein, we describe a 75 year-old gentleman who presented with fatigue and lethargy of 8 weeks duration. He was found to be anemic, with a mild lymphocytosis, decreased renal function, normal calcium level, and conspicuous M-Spike on serum electrophoresis. Furthermore, trephine bone marrow biopsy demonstrated two distinct hematological malignancies: CLL and MM.