Журнал цитокиновой биологии

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Understanding Immunogenicity: The Key to Effective Vaccines and Therapies

Gautam Kumar

Immunogenicity, a fundamental concept in immunology, encompasses the ability of substances to induce an
immune response in the body. This article provides an overview of immunogenicity, emphasizing its significance
in vaccine development, biologics, and therapeutic proteins. Factors influencing immunogenicity, including antigen
characteristics, host factors, adjuvants, and dosing regimens, are explored. The complex interplay of these
factors shapes the strength and specificity of immune responses. In the context of vaccines, the article delves
into the pivotal role of immunogenicity in clinical trials, with a focus on achieving robust and durable protection
against targeted pathogens. In biologics and therapies, the impact of anti-drug antibodies on safety and efficacy
is discussed, alongside strategies to mitigate immunogenicity risks. The article concludes by highlighting ongoing
challenges in understanding individual immune responses and envisioning future directions, such as personalized
medicine approaches and innovative vaccine platforms, to optimize immunogenicity.