Журнал цитокиновой биологии

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Understanding the Intricacies of Innate Immunity: Our First Line of Defence

Srikant Verma

Innate immunity constitutes the frontline defense mechanism against invading pathogens. It encompasses
physical barriers, phagocytes, natural killer cells, the complement system, inflammatory responses, and pattern
recognition receptors (PRRs) that collectively detect and neutralize potential threats. This immediate and nonspecific
defense mechanism plays a pivotal role in protecting the host from infections, bridging the gap to adaptive immunity,
and maintaining tissue homeostasis. However, it faces challenges from pathogens that evolve to evade detection,
prompting co-evolution between the immune system and infectious agents. A deeper understanding of innate
immunity is vital for improving our capacity to combat infections and bolster our overall immune responses.