Журнал молекулярной фармацевтики и исследований органических процессов

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Unveiling the Biological Potential of 2-Phenyl Indole Derivatives: A Comprehensive Review

Dhaneesh S, Swathi Lakshmi N, Lal Prasanth ML

This review furnishes a broad-gauge overview about the biological potential of 2-phenyl indole derivatives. Which have gained significant attention in the area of medicinal chemistry due to their immense biological potential? This review article presents a comprehensive overview of the diverse biological activities exhibited by these compounds, shedding light on their therapeutic applications and underlying mechanisms. Drawing upon a vast body of literature, we explore the wide range of pharmacological properties associated with 2-phenyl indole derivatives, including their anticancer, antimicrobial, anti-inflammatory, and neuroprotective effects. We delve into the intricate molecular pathways and targets engaged by these compounds, elucidating their mode of action. Additionally, we discuss the structure-activity relationship and physicochemical properties of 2-phenyl indole derivatives, providing insights into their design and optimization strategies. The synthesis methodologies employed for the production of these compounds are also examined, highlighting key synthetic routes and modifications. Furthermore, we assess the challenges and future prospects of utilizing 2-phenyl indole derivatives in drug discovery and development, emphasizing their potential as novel therapeutics. By presenting a comprehensive overview of the biological potential of 2-phenyl indole derivatives, this review serves as a valuable resource for researchers and scientists seeking to harness their medicinal prowess for the advancement of healthcare.