Журнал ортопедической онкологии

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Usage of MicroRNA in Potential Therapeutics of Ewing?s Sarcoma

Irena Boulytcheva

MicroRNAs (miRs) have recently emerged as important regulators of intracellular gene expression. In miR, which is often dysregulated in cancer, sheds new light on the molecular mechanisms of carcinogenesis and is of great interest as a biomarker and new therapies and targets. Recently, many studies have investigated the miR biology of Ewing sarcoma. The results indicate that changes in miR expression are widespread in Ewing sarcoma, including both carcinogenic EWS / Ets fusion-dependent and independent mechanisms, and contribute to a malignant phenotype.MiRs with potential prognosis have been identified, and several preclinical studies suggest that miR manipulation may be therapeutically useful for this invasive disease.