Журнал аналитических и биоаналитических методов

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With NMR Towards New Diagnostic Methods For Dengue

Camilla do Nascimento Bernardo, Marcela Cristina Oliveira Nogueira, Érika Pereira de Aquino, Sina Schmidtke, Elizandes Leal de Azeredo, Claire Fernandes Kubelka and Jochen Junker

Dengue is a very common viral disease in tropical countries. From time to time it has become epidemic, hindering economics and affecting the social system. Early starting treatment reduces recovery time and suffering of the patients. But, the usual diagnostics is done by detection of the antibodies, which can only be done after five days. Other parts of the metabolomics might change much faster and therefore the small molecule content in the blood might change much faster than that. By using NMR spectroscopy we attempted to differentiate blood plasma from infected patients from healthy subjects and afterwards identify the consistent changes. Several of these were found and are discussed.