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A unified model of Dementias and age-related Neurodegeneration: With an innovative and effective point of intervention

Michael Fossel

Both animal research and human clinical trials on age-related CNS diseases have suffered from the lack of a unified systems model. One result has been the failure of animal studies to translate into successful human trials, as well as the uniform failure of clinical trials aimed at targets such as amyloid, tau, etc. A unified model of agerelated CNS dysfunction needs to offer a framework for not only age-related human CNS diseases – including Alzheimer’s and other age-related human dementias -- but for age-related CNS dysfunction in animals as well. The model detailed here, focusing on cell senescence and the concomitant changes in gene expression, encompasses both human and animal disease and suggests a novel point of clinical intervention. It reviews the ten key questions required of such a model and offer potential answers to those questions. This model has excellent data support and predictive validity, precisely predicting previous trial results. In addition, the model is moving to FDA human trials to
validate its effectiveness as a feasible intervention.