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Intake of food pellets containing pre-germinated brown rice alleviates cognitive deficits caused by β-amyloid peptide25-35 in mice: Implication of lipid peroxidation

Takayoshi Mamiya, Makoto Ukai, Keiko Morikawa, Mitsuo Kise

In this study, we investigated whether the food pellets containing pre-germinated brown rice (PGBR; hatsuga genmai in Japanese) were effective on the impairments of cognitive function induced by ß-amyloid peptide25-35 (Aß25-35) in mice. To evaluate the effects of PGBR, mice were received AIN-93G (as control pellets) or PGBR-added food pellets (PGBR pellets) during this study. Aß25-35 (3 nmol/3 ßmol i.c.v.) was injected to mice on the day 22. On the days 30 and 31, we assessed the tasks related to visible cognition using novel object recognition tests. By the injection of Aß25-35 in the control pellets-fed mice impairments were observed, but the mice fed PGBR-added food pellets did not show the deficits. After the behavioral tests, we found Aß25-35 increased lipid peroxidation in the hippocampus of control pellets-fed mice but not PGBR pellets-fed mice. Taken together, these results suggest that continuous feeding of food pellets containing PGBR (i) attenuates the Aß25-35-induced impairments of cognitive function, and (ii) inhibited increases in lipid peroxidation in the hippocampus.